microglycodb_gene_00021

Gene Name lnbB    
UniProt ID B3TLD6
NOTES - phase variation etc lacto-N-biosidase
CAZy Family GH20
EC Number 3.2.1.140
PDB ID 4JAW 4H04
Sugar/modification added β-linked lacto-N-bioside (Galβ1,3GlcNAcβ1-O-R) and galacto-N-bioside (Galβ1,3GalNAcβ1-O-R). Very low activity on GA1.
Reviewed false
Organism Bifidobacterium bifidum
functions
sequence
publications
reaction
Data not found
Data not found

        10         20         30         40         50

MEKSSNRRFG VRTVAAIVAG LMVGGMCTAM TASAADDSAA GYSATAPVNL 

        60         70         80         90        100

TRPATVPSMD GWTDGTGAWT LGEGTRVVSS DALAARAQSL ASELTKFTDV 

       110        120        130        140        150

DIKAATGSAT GKDISLTLDA SKKAELGDEG FKLNIGSKGL EVIGATDIGV 

       160        170        180        190        200

FYGTRSVSQM LRQGQLTLPA GTVATKPKYK ERGATLCACQ INISTDWIDR 

       210        220        230        240        250

FLSDMADLRL NYVLLEMKLK PEEDNTKKAA TWSYYTRDDV KKFVKKANNY 

       260        270        280        290        300

GIDVIPEINS PGHMNVWLEN YPEYQLADNS GRKDPNKLDI SNPEAVKFYK 

       310        320        330        340        350

TLIDEYDGVF TTKYWHMGAD EYMIGTSFDN YSKLKTFAEK QYGAGATPND 

       360        370        380        390        400

AFTGFINDID KYVKAKGKQL RIWNDGIVNT KNVSLNKDIV IEYWYGAGRK 

       410        420        430        440        450

PQELVQDGYT LMNATQALYW SRSAQVYKVN AARLYNNNWN VGTFDGGRQI 

       460        470        480        490        500

DKNYDKLTGA KVSIWPDSSY FQTENEVEKE IFDGMRFISQ MTWSDSRPWA 

       510        520        530        540        550

TWNDMKADID KIGYPLDIRE YDYTPVDAGI YDIPQLKSIS KGPWELITTP 

       560        570        580        590        600

DGYYQMKDTV SGKCLALFTG SKHLDVVTQV GARPELRNCA DVSVGQDQRN 

       610        620        630        640        650

TANERNTQKW QIRADKDGKY TISPALTQQR LAIATGNEQN IDLETHRPAA 

       660        670        680        690        700

GTVAQFPADL VSDNALFTLT GHMGMSATVD SKTVNPASPS KITVKVRAAS 

       710        720        730        740        750

NANTGDVTVT PVVPEGWEIK PGSVSLKSIP AGKAAIAYFN VVNTTGTGDA 

       760        770        780        790        800

TVQFKLTNTK TGEELGTTSV ALTGSLTKDV EASDYAASSQ ETTGEHAPVG 

       810        820        830        840        850

NAFDKNANTF WHSKYSNPSA NLPHWLAFKA SPGEGNKIAA ITHLYRQDKL 

       860        870        880        890        900

NGPAKNVAVY VVAASDANSV ADVTNWGEPV ATAEFPYTKE LQTIALPNTI 

       910        920        930        940        950

PSGDVYVKFQ INDAWGLTET SAGVTWAAVA ELAATAKATP VELTEPEQPK 

       960        970        980        990       1000

DNPEVTETPE ATGVTVSGDG VANGALSLKK GTTAQLTAKV APDDADQAVT 

      1010       1020       1030       1040       1050

WASSDDKVVT VDKTGKVTAV AKGVAKVTAT TANGKSASVT VTVTEDSEVP 

      1060       1070       1080       1090       1100

GPTGPTEPTK PGTEKPTTKP TTKPNDGKLS ATGADTAVLA TIAALFALAG 

      1110       1120

GAVVAVRRRS VR




1. Bifidobacterium bifidum lacto-N-biosidase, a critical enzyme for the degradation of human milk oligosaccharides with a type 1 structure.

PubMed: 18469123

doi:10.1128/AEM.00149-08


2. Crystal structures of a glycoside hydrolase family 20 lacto-N-biosidase from Bifidobacterium bifidum.

PubMed: 23479733

doi:10.1074/jbc.M112.420109


3. Novel substrate specificities of two lacto-N-biosidases towards β-linked galacto-N-biose-containing oligosaccharides of globo H, Gb5, and GA1.

PubMed: 25839135

doi:10.1016/j.carres.2015.03.005


4. Gaining insight into the catalysis by GH20 lacto-N-biosidase using small molecule inhibitors and structural analysis.

PubMed: 26312778

doi:10.1039/c5cc05494j