microglycodb_gene_00023

Gene Name afcA    
UniProt ID Q6JV24
NOTES - phase variation etc 1,2-α-L-fucosidase
CAZy Family GH95
EC Number 3.2.1.63
PDB ID 2EAC 2EAE 2EAB 2EAD
Sugar/modification added α1,2-linked L-fucoside (specific for H-antigen Fucα1,2Gal). Very low activity on 3-FL (Galβ1-4(Fucα1,3)Glc).
Reviewed false
Organism Bifidobacterium bifidum
functions
sequence
publications
reaction
Data not found
Data not found

        10         20         30         40         50

MKHRAMSSRL MPLVASCATV GMLLAGLPVS AVAVGTTRAA ASDASSSTTA 

        60         70         80         90        100

TITPSADTTL QTWTSEKNSS MASKPYIGTL QGPSQGVFGE KFESTDAADT 

       110        120        130        140        150

TDLKTGLLTF DLSAYDHAPD SATFEMTYLG YRGNPTATDT DTIKVTPVDT 

       160        170        180        190        200

TVCTNNATDC GANVATGATK PKFSINDSSF VAESKPFEYG TTVYTGDAIT 

       210        220        230        240        250

VVPANTKKVT VDVTEIVRQQ FAEGKKVITL AVGETKKTEV RFASSEGTTS 

       260        270        280        290        300

LNGATADMAP KLTVSVSTKD DLKPSADTTL QAWASEKNEK KNTAAYVGAL 

       310        320        330        340        350

QPEGDYGDFG EKFKSTDVHD VTDAKMGLMT FDLSDYTAAP EHSILTLTYL 

       360        370        380        390        400

GYAGADKTAT ATDKVKVVAV DTSRCTGTAP CDTNNATWAN RPDFEVTDTT 

       410        420        430        440        450

KTATSHAFAY GSKKYSDGMT VESGNAKKVL LDVSDVIKAE FAKFSAGATE 

       460        470        480        490        500

KKITLALGEL NKSDMRFGSK EVTSLTGATE AMQPTLSVTK KPKAYTLSIE 

       510        520        530        540        550

GPTKVKYQKG EAFDKAGLVV KATSTADGTV KTLTEGNGED NYTIDTSAFD 

       560        570        580        590        600

SASIGVYPVT VKYNKDPEIA ASFNAYVIAS VEDGGDGDTS KDDWLWYKQP 

       610        620        630        640        650

ASQTDATATA GGNYGNPDNN RWQQTTLPFG NGKIGGTVWG EVSRERVTFN 

       660        670        680        690        700

EETLWTGGPG SSTSYNGGNN ETKGQNGATL RALNKQLANG AETVNPGNLT 

       710        720        730        740        750

GGENAAEQGN YLNWGDIYLD YGFNDTTVTE YRRDLNLSKG KADVTFKHDG 

       760        770        780        790        800

VTYTREYFAS NPDNVMVARL TASKAGKLNF NVSMPTNTNY SKTGETTTVK 

       810        820        830        840        850

GDTLTVKGAL GNNGLLYNSQ IKVVLDNGEG TLSEGSDGAS LKVSDAKAVT 

       860        870        880        890        900

LYIAAATDYK QKYPSYRTGE TAAEVNTRVA KVVQDAANKG YTAVKKAHID 

       910        920        930        940        950

DHSAIYDRVK IDLGQSGHSS DGAVATDALL KAYQRGSATT AQKRELETLV 

       960        970        980        990       1000

YKYGRYLTIG SSRENSQLPS NLQGIWSVTA GDNAHGNTPW GSDFHMNVNL 

      1010       1020       1030       1040       1050

QMNYWPTYSA NMGELAEPLI EYVEGLVKPG RVTAKVYAGA ETTNPETTPI 

      1060       1070       1080       1090       1100

GEGEGYMAHT ENTAYGWTAP GQSFSWGWSP AAVPWILQNV YEAYEYSGDP 

      1110       1120       1130       1140       1150

ALLDRVYALL KEESHFYVNY MLHKAGSSSG DRLTTGVAYS PEQGPLGTDG 

      1160       1170       1180       1190       1200

NTYESSLVWQ MLNDAIEAAK AKGDPDGLVG NTTDCSADNW AKNDSGNFTD 

      1210       1220       1230       1240       1250

ANANRSWSCA KSLLKPIEVG DSGQIKEWYF EGALGKKKDG STISGYQADN 

      1260       1270       1280       1290       1300

QHRHMSHLLG LFPGDLITID NSEYMDAAKT SLRYRCFKGN VLQSNTGWAI 

      1310       1320       1330       1340       1350

GQRINSWART GDGNTTYQLV ELQLKNAMYA NLFDYHAPFQ IDGNFGNTSG 

      1360       1370       1380       1390       1400

VDEMLLQSNS TFTDTAGKKY VNYTNILPAL PDAWAGGSVS GLVARGNFTV 

      1410       1420       1430       1440       1450

GTTWKNGKAT EVRLTSNKGK QAAVKITAGG AQNYEVKNGD TAVNAKVVTN 

      1460       1470       1480       1490       1500

ADGASLLVFD TTAGTTYTIT KKASANVPVT GVTVTGANTA TAGDTVTLTA 

      1510       1520       1530       1540       1550

TVAPANATDK SVTWSTSDAA VATVNANGVV TTKKAGKVTI TATSNGDKTK 

      1560       1570       1580       1590       1600

FGSIEITVSA ATVPVTSVTV AGDAAMTVDG EQTLTATVAP ATATDKTVTW 

      1610       1620       1630       1640       1650

KSSDATVATV DANGKVVAKK AGEVTITATA GGVSGTLKIT VSDKAPTVIP 

      1660       1670       1680       1690       1700

VQSVTVTGKQ ELVEGASTTL TATVAPADAT DKTVTWKSSD ESVATVDKDG 

      1710       1720       1730       1740       1750

VVTAKKAGTV TITATAGGVS GTLHITVTAK PVETVPVTSV EVTVEAGTTV 

      1760       1770       1780       1790       1800

SVGKTLQATA TVKPGNATNK KVTWKSSDES IATVDANGVI TAKKAGKVVI 

      1810       1820       1830       1840       1850

TATSTDGTDK SGSVEITVVD ETKPTPDHKS VKADTGDVTA GKTGTVTEPK 

      1860       1870       1880       1890       1900

DVAGWKSRSI IKQGKLGKAE IADGTLVYAA GDKTGDDSFV VQYTMADGTV 

      1910       1920       1930       1940       1950

IDVTYSVTVK AAETGKNDGD GKGDGVAKTG AAVGALAGLG LMLLAVGVSV 

      1960

VMIRRKHSA




1. Molecular cloning and characterization of Bifidobacterium bifidum 1,2-alpha-L-fucosidase (AfcA), a novel inverting glycosidase (glycoside hydrolase family 95).

PubMed: 15262925

doi:10.1128/JB.186.15.4885-4893.2004


2. Structural basis of the catalytic reaction mechanism of novel 1,2-alpha-L-fucosidase from Bifidobacterium bifidum.

PubMed: 17459873

doi:10.1074/jbc.M702246200