MicroGlycoDB

microglycodb_gene_00090

Gene Number	Cj1293
Gene Name	pseB
UniProt ID	Q0P8W4
NOTES - phase variation etc	UDP-GlcNAc-specific C4,6 dehydratase / C5 epimerase
Sugar/modification added
Reviewed	true
Biosynthesis	Flagellin O-glycan biosynthesis
Organism	Campylobacter jejuni

functions

sequence

publications

reaction

Data not found

Catalyzes the first step in the biosynthesis of pseudaminic acid, a sialic-acid-like sugar that is used to modify flagellin. Has both C6 dehydratase and C5 epimerase activities that result in the production of both UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-4-hexulose and UDP-2-acetamido-2,6-dideoxy-alpha-D-xylo-4-hexulose.

        10         20         30         40         50

MFNKKNILIT GGTGSFGKTY TKVLLENYKP NKIIIYSRDE LKQFEMASVF

        60         70         80         90        100

NAPCMRYFIG DVRDKERLSA AMRDVDFVIH AAAMKHVPIA EYNPMECIKT

       110        120        130        140        150

NIHGAQNVID ACFENGVKKC IALSTDKACN PVNLYGATKL ASDKLFVAAN

       160        170        180        190        200

NIAGNKQTRF GVTRYGNVVG SRGSVVPFFK KLISEGAKEL PITDTRMTRF

       210        220        230        240        250

WISLEDGVKF VLSNFERMHG GEIFIPKIPS MKITDLAHAL APNLSHKIIG

       260        270        280        290        300

IRAGEKLHEI MISSDDSHLT YEFENYYAIS PSIKFVDKDN DFSINALGEK

       310        320        330        340

GQKVKDGFSY SSDNNPLWAS EKELLEIINH TEGF

1. The genome sequence of the food-borne pathogen Campylobacter jejuni reveals hypervariable sequences.

PubMed: 10688204

doi:10.1038/35001088

2. Functional characterization of dehydratase/aminotransferase pairs from Helicobacter and Campylobacter: enzymes distinguishing the pseudaminic acid and bacillosamine biosynthetic pathways.

PubMed: 16286454