microglycodb_gene_00123

Gene Number Cj1327
Gene Name neuB2    
UniProt ID Q0P8T1
NOTES - phase variation etc N-acetylneuraminic acid synthetase
Sugar/modification added
Reviewed true
Biosynthesis Flagellin O-glycan biosynthesis
Organism Campylobacter jejuni
functions
sequence
publications
reaction
Data not found

 Involved in biosynthesis of legionaminic acid (5,7-diamino-3,5,7,9-tetradeoxy-D-glycero-D-galacto-non-2-ulosonic acid)(Leg), a sialic acid-like derivative that is incorporated into flagellin via O-linkage to Ser/Thr. Catalyzes the condensation of 2,4-diacetamido-2,4,6-trideoxymannose with phosphoenolpyruvate (PEP) to give N,N'-diacetyllegionaminic acid.

        10         20         30         40         50

MKKTLIIAEA GVNHNGDLNL AKKLIEIAAD SGADFVKFQS FKAKNCISTK 

        60         70         80         90        100

AKKAPYQLKT TANDESQLQM VQKLELDLKA HKELILHAKK CNIAFLSTPF 

       110        120        130        140        150

DLESVDLLNE LGLKIFKIPS GEITNLPYLK KIAKLNKKII LSTGMANLGE 

       160        170        180        190        200

IEEALNVLCK NGAKRQNITL LHCTTEYPAP FNEVNLKAMQ SLKDAFKLDV 

       210        220        230        240        250

GYSDHTRGIH ISLAAVALGA CVIEKHFTLD KNMSGPDHKA SLEPQELKML 

       260        270        280        290        300

CTQIRQIQKA MGDGIKKASK SEQKNINIVR KSLVAKKDIK KGEIFSEGNL 

       310        320        330        340

TTKRPANGIS AMRYEEFLGK IATKNYKEDE LIRE




1. The genome sequence of the food-borne pathogen Campylobacter jejuni reveals hypervariable sequences.

PubMed: 10688204

doi:10.1038/35001088


2. The CMP-legionaminic acid pathway in Campylobacter: biosynthesis involving novel GDP-linked precursors.

PubMed: 19282391

doi:10.1093/glycob/cwp039