microglycodb_gene_00140
| Gene Number | Cj1121c |
|---|---|
| Gene Name | pglE |
| UniProt ID | Q0P9D3 |
| NOTES - phase variation etc | UDP-4-keto-6-deoxy-GlcNAc C4 aminotransferase |
| Sugar/modification added | diNAcBac biosynthesis |
| Reviewed | true |
| Biosynthesis | N-glycan biosynthesis |
| Organism | Campylobacter jejuni |
functions
sequence
publications
reaction
Data not found
Aminotransferase involved in the bacillosamine biosynthesis pathway by producing UDP-4-amino-4,6-dideoxy-alpha-D-GlcNAc (UDP-2-acetamido-4-amino-2,4,6-trideoxy-alpha-D-glucopyranose), a precursor used in the production of the glycan component 2,4-diacetamido-2,4,6-trideoxy-alpha-D-glucopyranose. Required for host colonization and virulence. Involved in the N-linked protein glycosylation pathway.
10 20 30 40 50
MRFFLSPPHM GGNELKYIEE VFKSNYIAPL GEFVNRFEQS VKAYSKSENA
60 70 80 90 100
LALNSATAAL HLALRVAGVK QDDIVLASSF TFIASVAPIC YLKAKPVFID
110 120 130 140 150
CDETYNIDVD LLKLAIKECE KKPKALILTH LYGNAAKMDE IVEICKENEI
160 170 180 190 200
VLIEDAAEAL GSFYKNKALG TFGEFGAYSY NGNKIITTSG GGMLIGKNKE
210 220 230 240 250
KIEKARFYST QARENCLHYE HLDYGYNYRL SNVLGAIGVA QMEVLEQRVL
260 270 280 290 300
KKREIYEWYK EFLGECFSFL DELENSRSNR WLSTALIDFD KNELNSCQKD
310 320 330 340 350
INISQKNITL HPKISKLIED LKNEQIETRP LWKAMHAQEV FKGAKAYLNG
360 370 380 390
NSELFFQKGI CLPSGTAMSK DDVYEISKLI LKSIKA
1. The genome sequence of the food-borne pathogen Campylobacter jejuni reveals hypervariable sequences.
PubMed: 10688204
doi:10.1038/35001088
2. Functional characterization of dehydratase/aminotransferase pairs from Helicobacter and Campylobacter: enzymes distinguishing the pseudaminic acid and bacillosamine biosynthetic pathways.
PubMed: 16286454
doi:10.1074/jbc.m511021200
3. Cj1121c, a novel UDP-4-keto-6-deoxy-GlcNAc C-4 aminotransferase essential for protein glycosylation and virulence in Campylobacter jejuni.
PubMed: 16690622
doi:10.1074/jbc.m511714200