MicroGlycoDB

microglycodb_gene_00143

Gene Number	Cj1124c
Gene Name	pglC
UniProt ID	Q0P9D0
NOTES - phase variation etc	Undecaprenyl phosphate N,N'-diacetylbacillosamine 1-phosphate transferase
Sugar/modification added	diNAcBac transferase to form Und-PP-diNAcBac
Reviewed	true
Biosynthesis	N-glycan biosynthesis
Organism	Campylobacter jejuni

functions

sequence

publications

reaction

Data not found

Glycosyl-1-phosphate transferase that mediates the first step in the biosynthesis of the undecaprenyl-linked heptasaccharide donor in the N-linked protein glycosylation pathway. Catalyzes the linking of uridine 5'-diphosphobacillosamine (UDP-Bac) to undecaprenyl phosphate to create the first membrane-associated intermediate undecaprenylpyrophosphate-linked Bac (Und-PP-Bac).

        10         20         30         40         50

MYEKVFKRIF DFILALVLLV LFSPVILITA LLLKITQGSV IFTQNRPGLD

        60         70         80         90        100

EKIFKIYKFK TMSDERDEKG ELLSDELRLK AFGKIVRSLS LDELLQLFNV

       110        120        130        140        150

LKGDMSFVGP RPLLVEYLPL YNKEQKLRHK VRPGITGWAQ VNGRNAISWQ

       160        170        180        190        200

KKFELDVYYV KNISFLLDLK IMFLTALKVL KRSGVSKEGH VTTEKFNGKN

1. The genome sequence of the food-borne pathogen Campylobacter jejuni reveals hypervariable sequences.

PubMed: 10688204

doi:10.1038/35001088

2. Direct biochemical evidence for the utilization of UDP-bacillosamine by PglC, an essential glycosyl-1-phosphate transferase in the Campylobacter jejuni N-linked glycosylation pathway.

PubMed: 16618123