MicroGlycoDB

microglycodb_gene_00153

Gene Number	Cj1415c
Gene Name
UniProt ID	Q0P8J9
NOTES - phase variation etc	Cytidine diphosphoramidate kinase
Sugar/modification added	Nucleotide-activated phosphoramidate biosynthesis
Reviewed	true
Biosynthesis	Capsular polysaccharide biosynthesis
Organism	Campylobacter jejuni

functions

sequence

publications

reaction

Data not found

Involved in the biosynthesis of the O-methyl phosphoramidate (MeOPN) group found on the capsular polysaccharide (CPS) of C.jejuni (PubMed:17675288). Catalyzes the ATP-dependent phosphorylation of cytidine diphosphoramidate (CDP-NH(2)) to form cytidine 3'-phosphate 5'-diphosphoramidate (PubMed:29578334). Can also use other substrates such as the corresponding adenine and uridine diphosphoramidate derivatives or cytidine diphosphoramidate analogs, with lower efficiency (PubMed:29578334).

        10         20         30         40         50

MKNNPYIIWL TGLAGSGKTT IGQALYEKLK LKYKNLIYLD GDELREILGH

        60         70         80         90        100

YAYDRQGRID MALKRAKFAK FLNDQGMMVI VTTISMFNEI YDYNRKQLKN

       110        120        130        140        150

YYEIYIECDM HELIQRDQKG LYTKALNKEI DNVVGVDIEF DKPEADLVIN

       160        170        180

NSCRNNLEEK VELIIKKLAL

1. The genome sequence of the food-borne pathogen Campylobacter jejuni reveals hypervariable sequences.

PubMed: 10688204

doi:10.1038/35001088

2. Commonality and biosynthesis of the O-methyl phosphoramidate capsule modification in Campylobacter jejuni.

PubMed: 17675288

doi:10.1074/jbc.m704413200

3. Cytidine diphosphoramidate kinase: an enzyme required for the biosynthesis of the O-methyl phosphoramidate modification in the capsular polysaccharides of Campylobacter jejuni.

PubMed: 29578334