MicroGlycoDB

microglycodb_gene_00350

Gene Number	Rv2610c
Gene Name	pimA
UniProt ID	P9WMZ5
Protein Name
Reviewed	true
Biosynthesis	PIMs
Organism	Mycobacterium tuberculosis

functions

sequence

publications

reaction

Data not found

Involved in the biosynthesis of phosphatidyl-myo-inositol mannosides (PIM) which are early precursors in the biosynthesis of lipomannans (LM) and lipoarabinomannans (LAM). Catalyzes the addition of a mannosyl residue from GDP-D-mannose (GDP-Man) to the position 2 of the carrier lipid phosphatidyl-myo-inositol (PI) to generate a phosphatidyl-myo-inositol bearing an alpha-1,2-linked mannose residue (PIM1) (PubMed:15939292). PimA plays an essential role for growth in macrophages and during both the acute and chronic phases of infection (PubMed:25049093).

        10         20         30         40         50

MRIGMICPYS FDVPGGVQSH VLQLAEVMRT RGHLVSVLAP ASPHAALPDY

        60         70         80         90        100

FVSGGRAVPI PYNGSVARLR FGPATHRKVK KWLAHGDFDV LHLHEPNAPS

       110        120        130        140        150

LSMLALNIAE GPIVATFHTS TTKSLTLTVF QGILRPMHEK IVGRIAVSDL

       160        170        180        190        200

ARRWQMEALG SDAVEIPNGV DVDSFASAAR LDGYPRQGKT VLFLGRYDEP

       210        220        230        240        250

RKGMAVLLDA LPKVVQRFPD VQLLIVGHGD ADQLRGQAGR LAAHLRFLGQ

       260        270        280        290        300

VDDAGKASAM RSADVYCAPN TGGESFGIVL VEAMAAGTAV VASDLDAFRR

       310        320        330        340        350

VLRDGEVGHL VPVDPPDLQA AALADGLIAV LENDVLRERY VAAGNAAVRR

       360        370        380

YDWSVVASQI MRVYETVAGS GAKVQVAS

1. Expression and purification of a functionally active recombinant GDP-mannosyltransferase (PimA) from Mycobacterium tuberculosis H37Rv.

PubMed: 15939292

doi:10.1016/j.pep.2005.03.015

2. targetTB: a target identification pipeline for Mycobacterium tuberculosis through an interactome, reactome and genome-scale structural analysis.

PubMed: 19099550

doi:10.1186/1752-0509-2-109

3. Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.

PubMed: 21969609

doi:10.1074/mcp.M111.011445

4. Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.

PubMed: 21969609

doi:10.1074/mcp.m111.011627

5. The phosphatidyl-myo-inositol mannosyltransferase PimA is essential for Mycobacterium tuberculosis growth in vitro and in vivo.

PubMed: 25049093

doi:10.1128/jb.01346-13

6. Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.

PubMed: 9634230