MicroGlycoDB

microglycodb_gene_00352

Gene Number	Rv2688c
Gene Name	PimB’
UniProt ID	P9WQL7
Protein Name
Reviewed	true
Biosynthesis	PIMs
Organism	Mycobacterium tuberculosis

functions

sequence

publications

reaction

Data not found

Part of the ABC transporter complex Rv2686c/Rv2687c/Rv2688c involved in fluoroquinolones export. Confers resistance to ciprofloxacin and, to a lesser extent, norfloxacin, moxifloxacin and sparfloxacin. Probably responsible for energy coupling to the transport system.

        10         20         30         40         50

MTALNRAVAS ARVGTEVIRV RGLTFRYPKA AEPAVRGMEF TVGRGEIFGL

        60         70         80         90        100

LGPSGAGKST TQKLLIGLLR DHGGQATVWD KEPAEWGPDY YERIGVSFEL

       110        120        130        140        150

PNHYQKLTGY ENLRFFASLY AGATADPMQL LAAVGLADDA HTLVGKYSKG

       160        170        180        190        200

MQMRLPFARS LINDPELLFL DEPTSGLDPV NARKIKDIIV DLKARGRTIF

       210        220        230        240        250

LTTHDMATAD ELCDRVAFVV DGRIVALDSP TELKIARSRR RVRVEYRGDG

       260        270        280        290        300

GGLETAEFGM DGLADDPAFH SVLRNHHVET IHSREASLDD VFVEVTGRQL

1. Rv2686c-Rv2687c-Rv2688c, an ABC fluoroquinolone efflux pump in Mycobacterium tuberculosis.

PubMed: 15273144

doi:10.1128/aac.48.8.3175-3178.2004

2. Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.

PubMed: 9634230