MicroGlycoDB

microglycodb_gene_00355

Gene Number	Rv1159
Gene Name	pimE
UniProt ID	P9WN01
Protein Name
Reviewed	true
Biosynthesis	PIMs
Organism	Mycobacterium tuberculosis

functions

sequence

publications

reaction

Data not found

Catalyzes the alpha-1,2 addition of a mannose residue from polyprenol-phosphate-mannose (PPM) to a monoacyl phosphatidylinositol pentamannoside (AcPIM5) to generate a monoacyl phosphatidylinositol hexamannoside (AcPIM6).

        10         20         30         40         50

MCRTLIDGPV RSAIAKVRQI DTTSSTPAAA RRVTSPPARE TRAAVLLLVL

        60         70         80         90        100

SVGARLAWTY LAPNGANFVD LHVYVSGAAS LDHPGTLYGY VYADQTPDFP

       110        120        130        140        150

LPFTYPPFAA VVFYPLHLVP FGLIALLWQV VTMAALYGAV RISQRLMGGT

       160        170        180        190        200

AETGHFAAML WTAIAIWIEP LRSTFDYGQI NVLLMLAALW AVYTPRWWLS

       210        220        230        240        250

GLLVGVASGV KLTPAITAVY LVGVRRLHAA AFSVVVFLAT VGVSLLVVGD

       260        270        280        290        300

EARYYFTDLL GDAGRVGPIA TSFNQSWRGA ISRILGHDAG FGPLVLAAIA

       310        320        330        340        350

STAVLAILAW RALDRSDRLG KLLVVELFGL LLSPISWTHH WVWLVPLMIW

       360        370        380        390        400

LIDGPARERP GARILGWGWL VLTIVGVPWL LSFAQPSIWQ IGRPWYLAWA

       410        420        430        440

GLVYVVATLA TLGWIAASER YVRIRPRRMA N

1. PimE is a polyprenol-phosphate-mannose-dependent mannosyltransferase that transfers the fifth mannose of phosphatidylinositol mannoside in mycobacteria.

PubMed: 16803893

doi:10.1074/jbc.m604214200

2. Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.

PubMed: 21969609

doi:10.1074/mcp.M111.011445

3. Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.

PubMed: 21969609

doi:10.1074/mcp.m111.011627

4. Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.

PubMed: 9634230