MicroGlycoDB

microglycodb_gene_00363

Gene Number	Rv2673
Gene Name	aftC
UniProt ID	P9WMZ7
Protein Name
Reviewed	true
Biosynthesis	LAM
Organism	Mycobacterium tuberculosis

functions

sequence

publications

reaction

Data not found

Involved in the biosynthesis of the arabinogalactan (AG) region of the mycolylarabinogalactan-peptidoglycan (mAGP) complex, an essential component of the mycobacterial cell wall. Catalyzes the addition of an arabinofuranosyl (Araf) residue from the sugar donor decaprenyl-phospho-arabinose (DPA) on the C-3 of an alpha-(1->5)-linked Araf from the arabinan backbone of AG. It can also use (Z,Z)-farnesylphosphoryl D-arabinose (Z-FPA), and to a lesser extent (E,E,Z,Z,Z,Z)-heptaprenylphosphoryl D-arabinose (Z-HPA) and (Z)-nerylphosphoryl D-arabinose (Z-NPA) as sugar donors.

        10         20         30         40         50

MYGALVTAAD SIRTGLGASL LAGFRPRTGA PSTATILRSA LWPAAVLSVL

        60         70         80         90        100

HRSIVLTTNG NITDDFKPVY RAVLNFRRGW DIYNEHFDYV DPHYLYPPGG

       110        120        130        140        150

TLLMAPFGYL PFAPSRYLFI SINTAAILVA AYLLLRMFNF TLTSVAAPAL

       160        170        180        190        200

ILAMFATETV TNTLVFTNIN GCILLLEVLF LRWLLDGRAS RQWCGGLAIG

       210        220        230        240        250

LTLVLKPLLG PLLLLPLLNR QWRALVAAVV VPVVVNVAAL PLVSDPMSFF

       260        270        280        290        300

TRTLPYILGT RDYFNSSILG NGVYFGLPTW LILFLRILFT AITFGALWLL

       310        320        330        340        350

YRYYRTGDPL FWFTTSSGVL LLWSWLVMSL AQGYYSMMLF PFLMTVVLPN

       360        370        380        390        400

SVIRNWPAWL GVYGFMTLDR WLLFNWMRWG RALEYLKITY GWSLLLIVTF

       410        420        430        440

TVLYFRYLDA KADNRLDGGI DPAWLTPERE GQR

1. Biosynthesis of mycobacterial arabinogalactan: identification of a novel alpha(1-->3) arabinofuranosyltransferase.

PubMed: 18627460

doi:10.1111/j.1365-2958.2008.06354.x

2. Reconstitution of functional mycobacterial arabinosyltransferase AftC proteoliposome and assessment of decaprenylphosphorylarabinose analogues as arabinofuranosyl donors.

PubMed: 21595486

doi:10.1021/cb200091m

3. Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.

PubMed: 21969609

doi:10.1074/mcp.M111.011445

4. Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.

PubMed: 21969609

doi:10.1074/mcp.m111.011627

5. Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.

PubMed: 9634230