MicroGlycoDB

microglycodb_gene_00365

Gene Number	Rv3726c
Gene Name	aftD
UniProt ID	P96419
Protein Name
Reviewed	true
Biosynthesis	LAM
Organism	Mycobacterium tuberculosis

functions

sequence

publications

reaction

Data not found

Involved in the biosynthesis of the arabinogalactan (AG) region of the mycolylarabinogalactan-peptidoglycan (mAGP) complex, an essential component of the mycobacterial cell wall. Catalyzes the addition of an arabinofuranosyl (Araf) residue from the sugar donor decaprenyl-phospho-arabinose (DPA) on the C-3 of an alpha-(1->5)-linked Araf from the arabinan backbone of AG.

        10         20         30         40         50

MAPLSRKWLP VVGAVALALT FAQSPGQVSP DTKLDLTANP LRFLARATNL

        60         70         80         90        100

WNSDLPFGQA QNQAYGYLFP HGTFFVIGHL LGVPGWVTQR LWWAVLLTVG

       110        120        130        140        150

FWGLLRVAEA LGVGGPSSRV VGAVAFALSP RVLTTLGSIS SETLPMMLAP

       160        170        180        190        200

WVLLPTILAL RGTSGRSVRA LAAQAGLAVA LMGAVNAIAT LAGCLPAVIW

       210        220        230        240        250

WACHRPNRLW WRYTAWWLLA MALATLWWVM ALTQLHGVSP PFLDFIESSG

       260        270        280        290        300

VTTQWSSLVE VLRGTDSWTP FVAPNATAGA PLVTGSAAIL GTCLVAAAGL

       310        320        330        340        350

AGLTSPAMPA RGRLVTMLLV GVVLLAVGHR GGLASPVAHP VQAFLDAAGT

       360        370        380        390        400

PLRNVHKVGP VIRLPLVLGL AQLLSRVPLP GSAPRPAWLR AFAHPERDKR

       410        420        430        440        450

VAVAVVALTA LMVSTSLAWT GRVAPPGTFG ALPQYWQEAA DWLRTHHAAT

       460        470        480        490        500

PTPGRVLVVP GAPFATQVWG TSHDEPLQVL GDGPWGVRDS IPLTPPQTIR

       510        520        530        540        550

ALDSVQRLFA AGRPSAGLAD TLARQGISYV LVRNDLDPET SRSARPILLH

       560        570        580        590        600

RSIAGSPGLA KLAEFGAPVG PDPLAGFVND SGLRPRYPAI EIYRVSAPAN

       610        620        630        640        650

PGAPYFAATD QLARVDGGPE VLLRLDERRR LQGQPPLGPV LMTADARAAG

       660        670        680        690        700

LPVPQVAVTD TPVARETDYG RVDHHSSAIR APGDARHTYN RVPDYPVPGA

       710        720        730        740        750

EPVVGGWTGG RITVSSSSAD ATAMPDVAPA SAPAAAVDGD PATAWVSNAL

       760        770        780        790        800

QAAVGQWLQV DFDRPVTNAV VTLTPSATAV GAQVRRILIE TVNGSTTLRF

       810        820        830        840        850

DEAGKPLTAA LPYGETPWVR FTAAATDDGS AGVQFGITDL AITQYDASGF

       860        870        880        890        900

AHPVQLRHTV LVPGPPPGSA IAGWDLGSEL LGRPGCAPGP DGVRCAASMA

       910        920        930        940        950

LAPEEPANLS RTLTVPRPVS VTPMVWVRPR QGPKLADLIA APSTTRASGD

       960        970        980        990       1000

SDLVDILGSA YAAADGDPAT AWTAPQRVVQ HKTPPTLTLT LPRPTVVTGL

      1010       1020       1030       1040       1050

RLAASRSMLP AHPTVVAINL GDGPQVRQLQ VGELTTLWLH PRVTDTVSVS

      1060       1070       1080       1090       1100

LLDWDDVIDR NALGFDQLKP PGLAEVVVLS AGGAPIAPAD AARNRARALT

      1110       1120       1130       1140       1150

VDCDHGPVVA VAGRFVHTSI RTTVGALLDG EPVAALPCER EPIALPAGQQ

      1160       1170       1180       1190       1200

ELLISPGAAF VVDGAQLSTP GAGLSSATVT SAETGAWGPT HREVRVPESA

      1210       1220       1230       1240       1250

TSRVLVVPES INSGWVARTS TGARLTPIAV NGWQQAWVVP AGNPGTITLT

      1260       1270       1280       1290       1300

FAPNSLYRAS LAIGLALLPL LALLAFWRTG RRQLADRPTP PWRPGAWAAA

      1310       1320       1330       1340       1350

GVLAAGAVIA SIAGVMVMGT ALGVRYALRR RERLRDRVTV GLAAGGLILA

      1360       1370       1380       1390       1400

GAALSRHPWR SVDGYAGNWA SVQLLALISV SVVAASVVAT SESRGQDRMQ

MAPLSRKWLPVVGAVALALTFAQSPGQVSPDTKLDLTANPLRFLARATNLWNSDLPFGQAQNQAYGYLFPHGTFFVIGHLLGVPGWVTQRLWWAVLLTVGFWGLLRVAEALGVGGPSSRVVGAVAFALSPRVLTTLGSISSETLPMMLAPWVLLPTILALRGTSGRSVRALAAQAGLAVALMGAVNAIATLAGCLPAVIWWACHRPNRLWWRYTAWWLLAMALATLWWVMALTQLHGVSPPFLDFIESSGVTTQWSSLVEVLRGTDSWTPFVAPNATAGAPLVTGSAAILGTCLVAAAGLAGLTSPAMPARGRLVTMLLVGVVLLAVGHRGGLASPVAHPVQAFLDAAGTPLRNVHKVGPVIRLPLVLGLAQLLSRVPLPGSAPRPAWLRAFAHPERDKRVAVAVVALTALMVSTSLAWTGRVAPPGTFGALPQYWQEAADWLRTHHAATPTPGRVLVVPGAPFATQVWGTSHDEPLQVLGDGPWGVRDSIPLTPPQTIRALDSVQRLFAAGRPSAGLADTLARQGISYVLVRNDLDPETSRSARPILLHRSIAGSPGLAKLAEFGAPVGPDPLAGFVNDSGLRPRYPAIEIYRVSAPANPGAPYFAATDQLARVDGGPEVLLRLDERRRLQGQPPLGPVLMTADARAAGLPVPQVAVTDTPVARETDYGRVDHHSSAIRAPGDARHTYNRVPDYPVPGAEPVVGGWTGGRITVSSSSADATAMPDVAPASAPAAAVDGDPATAWVSNALQAAVGQWLQVDFDRPVTNAVVTLTPSATAVGAQVRRILIETVNGSTTLRFDEAGKPLTAALPYGETPWVRFTAAATDDGSAGVQFGITDLAITQYDASGFAHPVQLRHTVLVPGPPPGSAIAGWDLGSELLGRPGCAPGPDGVRCAASMALAPEEPANLSRTLTVPRPVSVTPMVWVRPRQGPKLADLIAAPSTTRASGDSDLVDILGSAYAAADGDPATAWTAPQRVVQHKTPPTLTLTLPRPTVVTGLRLAASRSMLPAHPTVVAINLGDGPQVRQLQVGELTTLWLHPRVTDTVSVSLLDWDDVIDRNALGFDQLKPPGLAEVVVLSAGGAPIAPADAARNRARALTVDCDHGPVVAVAGRFVHTSIRTTVGALLDGEPVAALPCEREPIALPAGQQELLISPGAAFVVDGAQLSTPGAGLSSATVTSAETGAWGPTHREVRVPESATSRVLVVPESINSGWVARTSTGARLTPIAVNGWQQAWVVPAGNPGTITLTFAPNSLYRASLAIGLALLPLLALLAFWRTGRRQLADRPTPPWRPGAWAAAGVLAAGAVIASIAGVMVMGTALGVRYALRRRERLRDRVTVGLAAGGLILAGAALSRHPWRSVDGYAGNWASVQLLALISVSVVAASVVATSESRGQDRMQ

1. Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.

PubMed: 21969609

doi:10.1074/mcp.M111.011445

2. Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.

PubMed: 21969609

doi:10.1074/mcp.m111.011627

3. Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.

PubMed: 9634230