microglycodb_gene_00366

Gene Number Rv3805c
Gene Name aftB    
UniProt ID O53582
Protein Name
Reviewed true
Biosynthesis LAM
Organism Mycobacterium tuberculosis
functions
sequence
publications
reaction
Data not found

 Involved in the biosynthesis of the arabinogalactan (AG) region of the mycolylarabinogalactan-peptidoglycan (mAGP) complex, an essential component of the mycobacterial cell wall. Catalyzes the transfer of arabinofuranosyl (Araf) residues from the sugar donor decaprenyl-phospho-arabinose (DPA) to the arabinan domain to form terminal beta-(1->2)-linked Araf residues, which marks the end point for AG arabinan biosynthesis before decoration with mycolic acids.

        10         20         30         40         50

MVRVSLWLSV TAVAVLFGWG SWQRRWIADD GLIVLRTVRN LLAGNGPVFN 

        60         70         80         90        100

QGERVEANTS TAWTYLLYVG GWVGGPMRLE YVALALAMVL SLLGMVLLML 

       110        120        130        140        150

GTGRLYAPSL RGRRAIMLPA GALVYIAVPP ARDFATSGLE SGLVLAYLGL 

       160        170        180        190        200

LWWMMVCWSQ PLRARPDSQM FLGALAFVAG CSVLVRPEFA LIGGLALIMM 

       210        220        230        240        250

LIAARTWRRR VLIVLAGGFL PVAYQIFRMG YYGLLVPSTA LAKDAAGDKW 

       260        270        280        290        300

SQGMIYVSNF NRPYALWVPL VLSVPLGLLL MTARRRPSFL RPVLAPDYGR 

       310        320        330        340        350

VARAVQSPPA VVAFIVGSGV LQALYWIRQG GDFMHGRVLL APLFCLLAPV 

       360        370        380        390        400

GVIPILLPDG KDFSRETGRW LVGALSGLWL GIAGWSLWAA NSPGMGDDAT 

       410        420        430        440        450

RVTYSGIVDE RRFYAQATGH AHPLTAADYL DYPRMAAVLT ALNNTPEGAL 

       460        470        480        490        500

LLPSGNYNQW DLVPMIRPSS GTAPGGKPAP KPQHAVFFTN MGMLGMNVGL 

       510        520        530        540        550

DVRVIDQIGL VNPLAAHTER LKHARIGHDK NLFPDWVIAD GPWVKWYPGI 

       560        570        580        590        600

PGYIDQQWVT QAEAALQCPA TRAVLNSVRA PITLHRFLSN VLHSYEFTRY 

       610        620        630

RIDRVPRYEL VRCGLDVPDG PGPPPRE




1. Identification of a novel arabinofuranosyltransferase AftB involved in a terminal step of cell wall arabinan biosynthesis in Corynebacterianeae, such as Corynebacterium glutamicum and Mycobacterium tuberculosis.

PubMed: 17387176

doi:10.1074/jbc.m700271200


2. Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.

PubMed: 21969609

doi:10.1074/mcp.M111.011445


3. Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.

PubMed: 21969609

doi:10.1074/mcp.m111.011627


4. Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.

PubMed: 9634230

doi:10.1038/31159